By Drew Provan
This moment version of the ABC of medical Haematology is a finished and functional consultant to this extensive ranging speciality, overlaying the haematological features of such parts as pathology, molecular technological know-how, melanoma, and normal medication. it is a brief quantity together with chapters on all parts of haematology written through those who take care of those illnesses each day. The ebook offers descriptions of those ailments and describes the pathways desirous about prognosis and remedy. complete color is used all through this seriously illustrated publication, utilizing medical fabric and textual content packing containers to emphasize key issues. we've additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require broad previous wisdom.
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Additional info for ABC of Clinical Haematology (ABC Series)
Detection of the t(15;17) translocation or the PML: RARA transcript by PCR can be used both to confirm a diagnosis of APL and to monitor for the presence of minimal residual disease (MRD). Several other non-random chromosomal abnormalities, Biochemistry Abnormal renal function can occur secondary to hyperuricaemia (particularly in association with a high white blood cell count) and sepsis. Infiltration of the liver can cause abnormal liver function tests. Bone marrow aspirate and trephine biopsy A diagnosis of leukaemia can usually be made from a bone marrow aspirate alone.
Granules contain fibrinogen, VWF, etc. • Intravenous immunoglobulin p IIb/IIIa GP Platelet • Tranexamic acid • Desmopressin Platelet • Recombinant factor VIIa • Bone marrow transplantation Platelets are small anucleate cells produced predominantly by the bone marrow megakaryocytes as a result of budding of the cytoplasmic membrane. Megakaryocytes are derived from the haemopoietic stem cell, which is stimulated to differentiate to mature megakaryocytes under the influence of various cytokines, including thrombopoietin.
Idiopathic thrombocytopenic purpura Idiopathic thrombocytopenic purpura is a relatively common disorder and is the most frequent cause of an isolated thrombocytopenia without anaemia or neutropenia. In adults, it often presents insidiously, most frequently in women aged 15–50 years, and can be associated with other autoimmune diseases, in particular systemic lupus erythematosus or the primary antiphospholipid syndrome. In children, the onset is more acute and often follows a viral infection. The autoantibody produced is usually IgG, directed against antigens on the platelet membrane.
ABC of Clinical Haematology (ABC Series) by Drew Provan