By Norman Maclean
This e-book is ready transgenic animals--animals into which new genes were artificially brought. It has chapters by means of major specialists at the current state-of-play concerning the program of the transgenic expertise to assorted animal teams. Scientists have carried out experiments on an exceptional variety of animal kinds, starting from protozoan cells, via nematode worms and fruit flies to many larger vertebrates, and this publication offers an in-depth, up to date, finished and authoritative account of the paintings with all such animal forms. The most likely impression of transgenic animals at the way forward for agriculture and medication is especially nice. those animals supply an unequalled experimental procedure for the learn of gene law, genetic facets of ailment, and gene treatment. one of many pursuits of the ebook is hence to set transgenic animals within the context in their current and destiny contributions to technological know-how and drugs.
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Extra info for Animals with Novel Genes
Wallace, R. & Whitelaw, C. B. A. (1993). Enhancing the efficiency of transgene expression. Phil. Trans. R. Soc. Lond. B 339, 225-32. Clothier, C. (1992). Report of the Committee on the Ethics of Gene Therapy. London: HMSO. Coghlan, A. (1992). Industry slams draft law on novel organisms. New Scientist, January, 20. Crawley, M. , Halles, R. , Kohn, D. & Buxton, J. (1993). Ecology of transgenic oilseed rape in natural habitats. Nature 363, 620-3. Dale, E. C. & Ow, D. W. (1991). Gene transfer with subsequent removal of the selection gene from the host genome.
This separation of 'vector' and 'helper' functions means that vector sequences can be integrated, generally as single copies, into the recipient genome, where they will remain stable, unless remobilized either by a further microinjection of 'helper' elements or purified P transposase (Kaufman & Rio 1991) or by the introduction of active P elements into the genome by way of a conventional cross. In principle, vector and 'helper' functions can be combined, but any introduced sequence would be capable of autonomous transposition and therefore unstable.
Transgenic animals will probably pose an equivalent threat. Whether we can spot the pests before they are released is surely the crucial question. References Argos, P. et al. (1986). The integrase family of site-specific recombinases. EMBO Jr. 5, 433-40. Brown, P. (1992). Gene therapy wins official blessing: Report on the Committee on the Ethics of Gene Therapy. New Scientist, January, 18. Bruggemann, E. P. (1993). Environmental safety issues for genetically modified animals. / . Anim. Sci. 71 (Suppl.
Animals with Novel Genes by Norman Maclean